BOC Sciences Improves Superparamagnetic Iron Oxide Nano
/Micro Particles Preparation for Chemotherapy Research
Having been serving the chemical industry for nearly two decades, BOC Sciences announces to continuously improve its Superparamagnetic Iron Oxide Nano/Micro Particles Preparation service, in order to help researchers engaged with chemotherapy study find a cure for some major diseases that are inflicting the human beings.
At present, nanoparticles are widely used as facilitators for laboratory diagnostics and therapeutics in various biomedical applications. They are good drug delivery agents, and more importantly, have negligible side effects in cancer therapy as well as treatment of other ailments. Among all types of nanoparticles, biocompatible superparamagnetic iron oxide nanoparticles with proper surface architecture and conjugated targeting ligands have attracted universal attention for drug delivery applications.
"Superparamagnetic iron oxide nanoparticles are composed of an iron oxide core surrounded by a hydrophilic polymer coating and are usually utilized as contrast agents for MR imaging. The combination of surface functionalization of SPIONs with other therapeutic molecules, such as antimicrobial agents, has been successfully applied in nanomedicine. Their magnetic properties are the greatest advantage, which allows direct delivery of matter into the pathogen zone without affecting the whole organism. This antimicrobial SPIONs model has incited an increasing interest," says a senior scientist from BOC Sciences.
The potential use of SPIONs are widely ranged. For now, they have been approved by the FDA for treatment of anemia in adult patients with chronic renal disease. They could also be used for noninvasive diagnosis of chronic liver diseases, including non-alcoholic fatty liver disease, nonalcoholic steatohepatitis, cirrhosis and liver tumors. In addition, they are also broadly used in bone marrow imaging, lymph node imaging, and atherosclerotic plaque imaging.
"Roughly speaking, at BOC Sciences we offer four related services: first, the synthesis of uniform superparamagnetic iron oxide microbeads with size ranging from a few nanometers to several micrometers. Second, we offer surface modification service with various coupling groups such as carboxylic acid, NHS-activated carboxylic ester and protein A. Third, we provide anti-fouling surface coating service, using our well-documented anti-fouling materials such asPEG and agarose. Four, we also offer service for the conjugation of different monoclonal antibodies to our magnetic beads for the effective and specific targeting of corresponding receptors expressed on cancer cell surface," continuously explained the scientist.
Besides, BOC Sciences also offers a range of ready-for-use, high-quality superparamagnetic iron oxide microbeads. For more information, please visit our website or send us an email.