BOC Sciences Newly Launches Targeted Protein Degradation Pla
New York, April 17, 2019—One of the world’s leading chemical vendors BOC Sciences announces to launch the Targeted Protein Degradation Platform in response to addressing customers’ concerns in finding a cure for difficult diseases.
“The idea is quite simple,” says Prof. Jones, a senior scientist from BOC Sciences. “Researchers want to develop protein degraders that can break into ubiquitin-proteasome machinery to change the destiny of disease-causing proteins. Aiming at this, they design small molecules with two active ends: one that binds to the protein of interest and the other that binds to a protein called E3 ubiquitin ligase. These bifunctional molecules force a handshake between the ubiquitin and the protein, sending it to the trash. They will keep on to repeat the same process, and as a result, quickly depleting levels of the unwanted protein.”
Ever since the initial design of proteolysis-targeting chimera (PROTAC) by Sakamoto et al. in 2001, this technology